Porcine osteosarcoma cells show cytogenetic abnormalities characteristic of human TP53-mutant osteosarcoma (Boehm et al., 2000), including abnormal giant nuclei, micronuclei and multinuclear cells with fragmented nuclei and atypical mitotic figures (Saalfrank et al., 2016). Here, TP53 is linked to osteosarcoma.