Additionally, MELK has been implicated in several other cancer-related processes, including cancer stem cell maintenance, chemotherapy resistance, anchorage-independent growth, and reactive oxygen species (ROS)-signaling (Wang et al., 2014; Ganguly et al., 2014a; Beke et al., 2015; Kim et al., 2015; Seong et al., 2016; Choi et al., 2011; Gu et al., 2013; Hebbard et al., 2010). Here, MELK is linked to cancer.