PDE10A and psychotic disorder: PDE10A inhibition by TAK‐063 at 0.3 mg/kg or more dose‐dependently upregulates cAMP and cGMP levels, activates their downstream signaling in the striatum, and produces potent antipsychotic‐like effects evaluated by METH‐ or MK‐801‐induced hyperactivity rodent models of psychosis.15, 17 Haloperidol at 0.3 mg/kg p.o. or olanzapine at 3 mg/kg p.o. also produced antipsychotic‐like effects in METH‐induced hyperactivity in rats.15 Thus, these dosages were used for the evaluation of pGluR1 in the rat striatum.