He impressively showed that NF‐κB is activated in cachectic muscle in both PAX 7 progenitor cells and myofibers.13, 14 Other studies buttress the view that increased forkhead box protein O (FoxO) signalling and the activation of the transcription factors NF‐κB, MuRF1 and muscle atrophy F‐box (MAFbx) in skeletal muscle play major roles during cachexia onset and progression.15, 16, 17 MuRF1 and MAFbx are essentially involved in muscle atrophy development. The gene discussed is FBXO32; the disease is Cachexia.