Notably, the expression of TLS‐related genes including CXCL13, CCL19 and CCL21, has been linked with a good prognosis in colorectal cancer14, 15 and melanoma.13 Interestingly, expression of a 3‐gene TLS signature comprising CXCL13, CCL19 and CCL21 was increased in patients with advanced GC. This evidence concerns the gene CCL21 and gastric cancer.