STAT3 and neoplasm: However while IL‐6 is primarily pro‐inflammatory, IL‐27 can preferentially activate STAT1 to exert suppressive effects on adaptive immune cells.42 For example, IL‐27 inhibits effector T cell responses, counteracts the IL‐6/STAT3 driven differentiation of Th17 cells and suppresses TLS development.22, 42, 43 Our analysis of gastric antrum in WT and gp130F/F mice revealed a comparable expression of Il27, suggesting that the development of tumour‐associated TLSs was independent of any inhibitory action potentially imposed by IL‐27.