Consequently, gastric tumourigenesis in gp130F/F mice is driven by STAT3 hyperactivation in response to the IL‐6 family cytokine, IL‐11.25, 26 The clinical relevance of the gp130F/F mouse model is illustrated by the observation that human GC tumours are associated with high IL‐11 expression and STAT3 hyperactivation.27, 28 Using the gp130F/F GC model, we reveal that the gp130/STAT3 signalling axis drives TLS development concomitant with a lymphoid chemokine signature, which although is associated with advanced GC in patients, does not indicate a favourable prognosis. This evidence concerns the gene IL6 and gastric cancer.