The CCI decrease in diabetes medication use was significantly greater than the changes in the UC group for all diabetes medications (P < 10−16) and all diabetes medications excluding metformin (P = 9.0 × 10−9), including sulfonylurea (P = 3.3 × 10−7) and insulin (P = 0.0002) (Fig. 3). This evidence concerns the gene INS and diabetes mellitus.