TNFRSF25 and Autoimmunity: The same effect does not appear to modulate disease in monogenic autoimmunity as none of the five individuals carrying the highest risk alleles for concurrent type 1 diabetes and coeliac disease—DR3/DR3 and DR3/DR4 [18]—had coeliac disease and only 3/14 with DR3/X had coeliac disease or AITD.