Beyond AMBRA1’s recognized role in embryonic development, neurological disorders and carcinogenesis, he showed that AMBRA1 can coordinate a cell response to starvation or other stresses by translocation of the autophagosome core complex to ER, by regulative ubiquitination and stabilization of the kinase ULK1, and by selective mitochondria removal and cell cycle down-regulation. The gene discussed is AMBRA1; the disease is nervous system disorder.