Indeed, an S. pyogenes-mediated dominant Th17 response via cutaneous lymphocyte antigen-positive T cell-dependent epidermal cell activation has been implicated in the features of keratinocytes in psoriasis, such as IL-17 production, and decreased filaggrin and loricrin expression (Ruiz-Romeu et al., 2016). The gene discussed is FLG; the disease is psoriasis.