Li et al. [52] demonstrated that 4h-steamed American ginseng root extract (S4h) accelerated apoptosis in colorectal cancer HCT-116 and SW-480 cells, which is mediated by mitochondria damage that initiates both the apoptosis pathway and the ROS/NF-κB mediated survival pathway. This evidence concerns the gene NFKB1 and colorectal cancer.