The pretreated with 50 μM compound K for 24 h enhanced tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human colon cancer HCT-116 and HT-29 cells through down-regulated Mcl-1, Bcl-2, survivin, X-linked inhibitor of apoptosis protein (XIAP), and Fas-associated death domain-like IL-1-converting enzyme-inhibitory protein (cFLIP), increased Bax, truncated Bid (tBid), Cyt C, Atg7, LC3-II, and via up-regulating autophagy-dependent and autophagy-independent death receptors 5 (DR5) (Figures 3 & 4) [56]. Here, TNF is linked to malignant colon neoplasm.