TP53 and breast cancer: Ginsenoside Rg3 was also proved to induce the apoptosis of human breast cancer MDA-MB-231 cells through up-regulating intracellular ROS generation that was characterized by a down-regulating of Bcl-2/Bax ratio, perturbation of the MTP leading to Cyt C release and initiation of the caspase-3 [67], and inhibiting constitutive activation of NF-κB signaling via probably deactivation of ERK and Akt (Protein kinase B) as well as destabilization of mutant p53 through enhancement of Mdm2 binding to mutant p53 protein, which may be responsible for inhibition of Bcl-2 expression [68].