NFKB1 and colorectal cancer: Ginsenoside Rh2 induced apoptosis and paraptosis-like cell death in colorectal cancer HCT-116 and SW-480 cells via the activation of both the p53 and NF-κB signaling pathway through up-regulation the levels of ROS as well as Bax and Bad, while down-regulation the levels of Bcl-2 (Figure 3) [50].