ESR2 and esophageal cancer: A recent study showed that ginsenoside Ro inhibits autophagy by hampering with autophagosome-lysosome fusion and lysosomal proteolytic activity by enhancing lysosomal pH and reducing lysosomal cathepsins through the estrogen receptor 2 (ESR2)-neutrophil cytosolic factor 1 (NCF1)-ROS signaling pathway (Figure 4) and thereby sensitized esophageal cancer cells to5-fluorouracil-induced cell death via reduces CHEK1 (checkpoint kinase 1) degradation, increases CHEK1-mediated DNA damage checkpoint arrest [74].