PIK3CA and endometrial cancer: For example, mutations in the genes ERBB2, PIK3R1, TP53, and NF1 stand out in glioblastoma [9]; TP53, NF1, BRCA1, BRCA2, RB1, GABRA6, CSMD3, FAT3, and CDK12 alterations characterize ovarian cancer [10]; TP53, PTEN, CTNNB1, PIK3CA, ARID1A, KRAS, ARID5B, and POLE mutations are features of endometrial cancer [11]; TP53, RAS, EGFR, BRAF, PIK3CA, MET, RIT1, STK11, KEAP1, NF1, RB1, CDKN2A, SETD2, ARID1A, SMARCA4, RBM10, U2AF1, and MGA are hallmarks of lung cancer [12].