Overall, no significant association between GNβ3 C825T polymorphism and risk of IBS was observed under all genetic models (C vs. T, P = 0.194; CC vs. TT, P = 0.564; CT vs. TT, P = 0.594; CC + CT vs. TT, P = 0.430; CC vs. CT+TT, P = 0.462) (Figure 2). Here, GNB3 is linked to irritable bowel syndrome.