For example, the minor allele frequencies (MAF) of the SNP GNβ3 C825T (rs5443) is 0.50 in the East Asian population (EAS), whereas the MAF is 0.31 in the European population (EUR) and the MAF is 0.38 in the Ad Mixed American population (AMR) based on the data from the 1000 G. In accordance with our partial findings, a previous meta-analysis performed by Pan ZG et al. [31] found that no associations of GNB3 C825T polymorphism with IBS risk either in Asian population or Caucasian population. Here, GNB3 is linked to irritable bowel syndrome.