GNB3 and irritable bowel syndrome: The C allele of GNβ3 C825T was found to be significantly associated with a decreased risk of IBS-C in allele model (C vs. T, OR = 0.788, 95% CI: 0.622-0.997, P = 0.048), while no evidence of significance was identified in other genetic models (CC vs. TT, P = 0.073; CT vs. TT, P = 0.140; CC+CT vs. TT, P = 0.056; CC vs. CT+TT, P = 0.292).