EIF4E and cancer: Dephosphorylated active 4EBP1 binds to eukaryotic translation initiation factor 4E (eIF4E) and disrupts the formation of the cap-dependent translation initiation complex, comprising the eIF4A RNA helicase, the eIF4E mRNA cap-binding protein, and the eIF4G scaffolding protein, which is essential for protein synthesis and is associated with cancer development and progression [2].