INPP4B and breast carcinoma: It had been reported that breast cancer cells with p53 mutations exhibited impaired DNA damage response and increased sensitivity to poly-ADP ribose polymerase (PARP) inhibitors [10]; in addition, INPP4B was proposed as a tumor suppressor to modulate PI3K signaling and lapatinib was a tyrosine kinase inhibitor that could prevent triple-negative breast cancer metastasis to the brain [11, 12, 13].