Throughout the years of investigation Annexin A1 (AnxA1), Annexin A2 (AnxA2), Annexin A3 (AnxA3), Annexin A4 (AnxA4), Annexin A5 (AnxA5), Annexin A6 (AnxA6), and Annexin A8 (AnxA8) have all been identified as potential modulators of breast cancer progression. This evidence concerns the gene ANXA2 and breast cancer.