Over-expression of CCND1 or amplification at the 11q13 region is also associated with poor prognosis and relapses in high-grade gliomas (normal brain tissues, low-grade gliomas, and high-grade gliomas were 4/18, 15/32, and 18/24), oligodendrogliomas, and ependymomas on supratentorial locations [26–28]. Here, CCND1 is linked to central nervous system cancer.