We also observed: (a) the mRNA levels of both CCND1 and PGR were significantly higher in ER+-breast tumor tissues than in ER--breast tumor tissues (Figure 5A); (b) the mRNA levels of both CCND1 and PGR were significantly higher in ER+-breast tumor tissues than in their corresponding tumor-adjacent tissues (Figure 5B); and (c) they were significantly lower in ER--breast tumor tissues than in their corresponding tumor-adjacent tissues (Figure 5C). Here, ESR1 is linked to breast neoplasm.