Tumors of USP18 deficient mice also displayed an increased CD4+ T-cell infiltration, an increased level of cxcL-10 and hypersensitivity to IFN-λ enhanced up-regulation of CxcL-10 expression, which created a Th1/M1-polarized cytokine tumor environment and inhibited tumor progression [69]. This evidence concerns the gene CD4 and neoplasm.