It is worth noting that all of these genes except PGR (P<0.05) and CCND1 (P<0.01) which were down-regulated, were up-regulated in ER+ MCF-7 cells by 4-OH-TAM, confirming their pathophysiological relevance and possible involvement in mediating the anti-breast cancer effects of TAM. Here, ESR1 is linked to breast carcinoma.