The results shown in Figure 5C indicated that the mRNA levels of RBL2 (P<0.0001), SASH1 (P<0.001), PGR (P<0.001), CCND1 (P<0.01) and ANXA1 (P<0.0001) were all significantly lower in ER--cancer tissues than in their corresponding tumor-adjacent tissues while those of EIF2AK2 (P<0.05), S100A8 (P<0.001) and S100A9 (P<0.0001) were significantly higher in ER--cancer tissues than in their corresponding tumor-adjacent tissues. The gene discussed is S100A8; the disease is cancer.