Furthermore, we also attempted to examine the transcriptional profiles of TAM-regulated genes in both ER+- and ER--breast cancer cell lines and to compare their transcriptional expression profiles in ER+- and ER--breast tumor tissues with those of their corresponding tumor-adjacent tissues obtained from patients with breast cancer, aiming to reveal the pathophysiological relevance of TAM-regulated genes and mechanisms underlying TAM-anti-breast cancer effects. This evidence concerns the gene ESR1 and breast cancer.