USP18 and cancer: It can be seen from Figure 5B that the mRNA levels of EIF2AK2 (P<0.0001), TGM2 (P<0.05), USP18 (P<0.01), DDX58 (P<0.0001) PARP9 (P<0.0001), STAT2 (P<0.001), STAT1 (P<0.001), PGR (P<0.05) and CCND1 (P<0.01) were all significantly higher in cancer tissues than in their corresponding tumor-adjacent tissues.