No studies have reported the relationships between LVI and BCL11A expression, and studies on the associations between LVI and the expression of ER, PR, HER-2, Ki-67, CK5/6, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), E-cadherin and P53 in invasive breast cancer have produced controversial results. The gene discussed is VEGFA; the disease is invasive breast carcinoma.