The prognosis of breast cancer is determined by certain clinicopathological factors, including the presence or absence of lymph node metastasis, tumor size, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, human epidermal growth factor receptor-2 (HER-2) status, Ki-67 expression, and the presence or absence of lymphovascular invasion (LVI) [1]. The gene discussed is ESR1; the disease is neoplasm.