Here we demonstrate, to our knowledge, for the first time that protein levels of both CXCR3 isoforms are progressively upregulated in benign and malignant tumors where CXCR3A expression remains as the predominant isoform and promotes cell proliferation in Nthy-ori-3-1 by CXCL10 and CXCL11 stimulation. The gene discussed is CXCR3; the disease is cancer.