Since IFN-γ induces the secretion of CXCR3 ligands and CXCL10 in normal [51, 52] and PTC thyrocytes [53], it has been proposed that CXCR3 chemokines may promote thyroid malignant transformation and/or thyroid cancer progression [54–57]. The gene discussed is CXCR3; the disease is thyroid gland disorder.