An analysis for detection of expression quantitative trait loci revealed that CHRNA3 rs8040868-C allele was found to be closely associated with a decreased expression of the nearby gene CHRNA5 cholinergic receptor in lung tissue and conferred a risk for COPD, in which CHRNA3 and CHRNA5 are located in a tail-to-tail configuration on opposite DNA strands and share some of their 3′-untranslated region [13]. Here, CHRNA3 is linked to chronic obstructive pulmonary disease.