Notably, some synergistically expressed gene pairs in normal tissue became independently expressed in cancer (ANKRD36BP2-BCL2, PMS2L2-TNFRSF10D, PMS2L2-TNFRSF1A) or an independently expressed pair (HCG11-PPP3CB) in normal became antagonistically expressed in cancer. The gene discussed is TNFRSF10D; the disease is cancer.