Notably, the expressions of MALAT1 in highly metastatic samples with TNBC were significantly higher than those in highly metastatic samples with Her-2 positive breast cancer (Figure 1), implying that XBP1-HIF1α pathway was activated to a relatively great extent in TNBC and might be play more important roles in the metastatic process of TNBC. The gene discussed is XBP1; the disease is breast cancer.