Through the genetic models analyses as shown Table 2, we found that ApoB rs1042034 and rs673548 increased the risk of Ischemic Stroke under the log-additive model, the odds of having Ischemic Stroke would be 1.28-fold (OR=1.28, 95%CI: 1.02-1.60, p=0.034) and 1.27-fold (OR=1.27, 95%CI: 1.01-1.60, p=0.038) with the variant allele, respectively. Here, APOB is linked to ischemic stroke.