Furthermore, a number of key proteins, including cyclin D1 (which we have shown to repress AR activity [26]), receptor tyrosine kinases such as ALK and cMET as well as many members of the translation (e.g ribosomal S6 protein) and survival (e.g., BAD and LAMP2) signaling pathways were comparably expressed in the LCM and TDCM samples versus conventional CRC cultures (Supplementary Figure 3). The gene discussed is CCND1; the disease is colorectal carcinoma.