At present, there are also many other treatments for breast cancer bone metastasis, such as microRNA [41, 42], the small-molecule antagonist adrenomedullin [24], combination therapy, such as OPG in combination with tamoxifen [35], LGR4 target therapy [40], interferon (IFN)-based therapies [43], and others. The gene discussed is ADM; the disease is breast carcinoma.