On the other hand, recent studies in which limited comprehensive molecular profiling analyses were performed—especially those using next-generation sequencing—have revealed that several genes are altered in SDCs, including TP53 and genes related to cell signaling by receptor-tyrosine kinases, the PI3K/Akt pathway, and the RAS-MAPK cascade, which play integral roles in tumor growth and the survival of various types of carcinoma [8–17]. Here, PIK3CA is linked to neoplasm.