Uniquely by measuring all the parameters together we were able to determine that low levels of tumour E-cadherin, which appeared predictive of worse overall survival in univariate but not multivariate analysis, was a confounder of immune infiltration: presence of E-cadherin at moderate or high level was critical for the presence of CD8+ T cell, FoxP3+ T-regulatory cells and CD68+ macrophages in the tumour nests. The gene discussed is CD8A; the disease is neoplasm.