E-cadherin levels showed a correlation with high CD8 TN/STR (rank Spearman p=0.0435) and from this it was noted that those cells with low levels of E-cadherin had significantly lower numbers of CD8, FoxP3, and CD68 cells in the tumour nest but not in the stroma (Supplementary Figure 2) and hence lower TN/STR ratios (Figure 4B–4D). The gene discussed is CDH1; the disease is neoplasm.