In a preliminary study performed to measure the anti-cancer effect of rTRAIL in a gastric or colon cancer models, we recognized that the anti-cancer effect of rTRAIL involves multiple cancer pathways, including anti-inflammatory and anti-cancer actions of TRAIL on initiation, promotion, and progression of carcinogenesis as exemplified in Helicobacter pylori- or colitis-associated cancer (CAC). This evidence concerns the gene TNFSF10 and cancer.