EGFR and non-small cell lung carcinoma: In the present study, we demonstrated that M-COPA dispersed Golgi structure, downregulated cell surface expression of mutated EGFR and its downstream signals and exerted an antitumor effect on NSCLC cells harboring an activating EGFR mutation; however, the effect was modest when compared with EGFR-TKIs such as gefitinib.