Because we previously demonstrated that M-COPA prevented the maturation and transport of the MET protein to the cell surface to downregulate its downstream signaling pathway in MET-amplified gastric cancer cells [33], we expected that M-COPA might also downregulate MET expression in EGFR-TKI-resistant NSCLC cells. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.