Therefore, in order to evaluate the impact of statins (the main family of anticholesterolemic compounds, inhibitors of the mevalonate pathway enzyme Hydroxymethyl glutaryl CoA reductase - HMGCR) in PCa biology, we first evaluated the effect of statin exposure in the context of obesity in Pten prostate-specific heterozygous mice (Ptenpc+/-), which exhibit a weak, non-cancerous phenotype [10, 17]. Here, HMGCR is linked to obesity due to melanocortin 4 receptor deficiency.