CXCL8 and graft versus host disease: The Italian group has proven that even if the serum cytokine levels were related to several variables associated with HSCT, the two cytokines IL-8 and IL-2Rα are predictors of GVHD II-IV and III-IV, translating into a higher treatment-related mortality (TRM) risk (17% vs 3%, P=0.004).