AKT1 and colorectal carcinoma: Moreover, circ-BANP, generated from exons 5-11 of the BANP gene, is the most upregulated circRNA, and knockout of circ-BANP obviously reduced the proliferation rates of HT29 and HCT116 CRC cells by attenuating Akt/PKB (protein kinase B) phosphorylation [66].