EIF4G2 and cervical cancer: Similarly, through polysome profiling analysis, computational prediction and mass spectrometry in human embryonic kidney 293 cells and cervical cancer HeLa cells, Yang et al. identified hundreds of endogenous circRNAs with translation abilities, which were dependent on the motifs of N6-methyladenosine (m6A) in the sequence of the molecules, and the initiation factor eIF4G2 (eukaryotic translation initiation factor 4 gamma 2) and m6A reader YTHDF3 (YTH m6A RNA-binding protein 3) were shown to drive this m6A-mediated translation [35].