In NPC tissues, HOTAIR, H19, MALAT1, ANRIL, ROR and AFAP1-AS1 are up-regulated [64, 67, 72, 83, 86, 89], while LET, LINC0086, LOC401317 and LINC00312 are down-regulated [92–94, 96], which is correlated with their applications in treatment and prognosis. The gene discussed is AFAP1; the disease is nasopharyngeal carcinoma.