In 5-FU resistant SNUC5 colon cancer cells, OGT is overexpressed and interacts strongly with oxidative stress-activated ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and histone H3 lysine 4 (H3K4) methyltransferase SET1/COMPASS (complex proteins associated with SET1) complex involved in the activation of gene expression [161]. This evidence concerns the gene SETD1A and malignant colon neoplasm.