Treatment of CRC cells with benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside (benzyl-α-GalNAc), a structural analog of α-GalNAc linked to serine or threonine residue which competitively inhibits core 1 O-glycans extension, or benzyl-α-GalNAc-derived oligosaccharides has been shown to induce apoptosis [112] and reduce sensitivity to TNF-related apoptosis-inducing ligand (TRAIL) [113]. Here, TNFSF10 is linked to colorectal carcinoma.