A genome-wide mRNA expression profiling of the National Cancer Institute NCI-60 human tumor cell lines screen, comprising seven different colon cancer cell lines, revealed that OGT expression is negatively correlated with sensitivity to fluorodeoxyuridine monophosphate (FdUMP), the active metabolite of 5-FU responsible for TS inhibition (Figure 3; Table 1). This evidence concerns the gene TYMS and malignant colon neoplasm.