Oct4 (also called OTF3 or POU5F1), an embryonic transcription factor that binds to the octamer DNA sequence ATGC(A/T)AAT through its POU domain, is expressed in embryonic stem cells where it controls their survival and also their pluripotency by cooperating with different transcription factors such as Sox2 [111], and it is also uniformly expressed in the seminoma and embryonic carcinomas [112]. Here, POU5F1 is linked to embryonal carcinoma.