Overexpressed in seminomas and embryonal carcinomas and involved in important biological processes (regulation of telomerase activity, maintenance of genomic integrity, autophagy), MAPK15 has been reported to protect from ROS accumulation and DNA damage, therefore preventing p53 activation and p53-mediated cell cycle arrest, and thus favoring NTera2/D1 GCT-derived cell lines proliferation and tumorigenicity [141]. This evidence concerns the gene TP53 and granular cell tumor.