POU5F1 and neoplasm: Interestingly, in recent years the findings regarding the association of different genes, (e.g. c-KIT/KITLG, POU5F1) with the development of this neoplasia, and the identification of aberrant epigenetic patterns in promoter regions of several genes, along with the expression of specific regulatory cluster (miRnas), have shed a better light in the comprehension of the development of this disease.