C3 and psoriasis: We also evaluated the relation of sE-selectin, fibrinogen, and C3 serum levels to psoriasis and found they were increased in psoriasis patients (Figure 2, Supplementary Figures 15–17, sE-selectin: SMD = 1.90, 95% CI 1.07 to 2.74; Fibrinogen: SMD = 0.98, 95% CI 0.53 to 1.42; C3: SMD = 0.62, 95% CI 0.03 to 1.21).