In conclusion, serum levels of TNF-α, IFN-γ, IL-2, IL-6, IL-8, IL-18, IL-22, chemerin, lipocalin-2, resistin, sE-selectin, fibrinogen and C3 were significantly elevated and serum level of adiponectin was significantly decreased in psoriasis patients compared to healthy individuals. This evidence concerns the gene RARRES2 and psoriasis.