Mechanistic study has revealed that NSCLC lung tissues with low lncRNA-LET levels have stronger activated Notch1 (NICD1) expression than those with high lncRNA-LET levels, and that lncRNA-LET inhibits the Notch signaling pathway by targeting Notch1 in NSCLC cells. This evidence concerns the gene NOTCH1 and non-small cell lung carcinoma.