As expected, overall survival of the low CCAR2/high IL-8 group was shorter than that of the low CCAR2/low IL-8 and high CCAR2/low IL-8 groups (Figure 6C), suggesting that low CCAR2 expression is associated with high IL-8 expression and contributes to create aggressive tumor microenvironment. The gene discussed is CXCL8; the disease is neoplasm.