TP53 and Hepatic fibrosis: It has been reported that FOXO1 plays a crucial role in the transdifferentiation and the proliferation of HSCs in liver fibrosis [21]; APC, which negatively regulates Wnt signaling, is associated with liver fibrosis [22]; P53 can promote apoptosis and inhibit the proliferation of HSCs [23]; and RXRα can inhibit the HSCs proliferation and reverse the phenotype of activated HSCs [24].