HMGB1 and myocardial infarction: Interestingly, in a prior study, we have already demonstrated that cardiac ckit+ cells express RAGE and their regenerative responses, elicited by intramyocardial injection of exogenous High Mobility Group Box-1 protein (HMGB1) following acute MI, are mediated, at least in part, by the interaction HMGB1-RAGE [49].