SNAI2 and carcinoma: All six genes (CTNNB1, CDH2, Vimentin, Snail, Slug, and Zeb1) are positively associated with EMT activity; Snail, Slug, and Zeb1 function to repress E-cadherin, which typically adheres adjacent epithelial cells in carcinomas, leading to increased metastasis and EMT [48, 49].