In the presented study, we investigated a more detailed cellular distribution of FZD-10 in three different types of pathological tissue (colon cancer, melanoma and gastric cancer) and for different pathological stages (low and high dysplasia in colon and gastric tissue, tumor in situ, different cancer staging (T1–T4), and different type of metastases (hepatic metastases for colon and gastric cancer and lymphnode metastases for melanoma). This evidence concerns the gene FZD10 and melanoma.