We also observed that the proteins levels of phosphorylated c-Jun N-terminal kinase (p-JNK), phosphorylated focal adhesion kinase (p-FAK), phosphorylated glycogen synthase kinase 3β (p-GSK3β) and phosphorylated sarcoma (p-Src) were decreased in slowly growing tumor tissues following ESCCAL_1 knockdown (Figure 2A–2B). Here, MAPK8 is linked to neoplasm.