To determine whether PGK1 and GRP78 are independent prognostic factors for endometrial carcinoma, we performed multivariate analysis of PGK1 and GRP78 protein expression levels, adjusted for career, FIGO stage, histological grading, lymph node status, postoperative irradiation, and postoperative chemotherapy of endometrial carcinoma patients. This evidence concerns the gene HSPA5 and endometrial carcinoma.