We observed that the expression level of GRP78 was positively correlated with FIGO stage (I vs. II–III; P < 0.001), pathological type (adenocarcinoma vs. others; P = 0.0125), histological grade (G1 vs. G2 vs. G3; P = 0.019), and lymph node metastasis (negative vs. positive; P < 0.001) in endometrial carcinoma patients. Here, HSPA5 is linked to metastatic malignant neoplasm in the lymph nodes.