Expression of ANO1 was significantly associated with distant metastatic relapse (P < 0.001), latent bone metastasis (P = 0.011), and β-catenin expression (P = 0.002), cyclin D1 expression (P = 0.004), MMP expression (P = 0.023), and snail expression (P = 0.001) (Table 1). The gene discussed is ANO1; the disease is metastasis.