Since Let-7 microRNA has been shown to inhibit CASP3 expression, thereby promoting chemoresistance [19], and be negatively regulated by the NF-kB-Lin28 axis in breast cancer cells [20], we next analyzed the transcriptional profiles of OTUD7B, CASP3 and LIN28 in TNBC tissues. The gene discussed is NFKB1; the disease is breast carcinoma.