KEAP1 and neoplasm: The UBP pathway was altered in 7 tumours with mutations in TRIP12, FBXW7, KEAP1 and CYLD. In this UBP pathway, two genes less well known to be involved in human carcinogenesis were identified: TRIP12 and CYLD. These two putative tumour suppressor genes were located in chromosome 2q and 16q respectively that were frequently deleted in our series (Figure 2).