However, the knockdown of PPARδ abolished the HBXIP-induced proliferation (Figure 6A, 6B and Supplementary Figure 4A), the similar results were also confirmed by colony formation assays (Supplementary Figure 4B), suggesting that HBXIP promoted the proliferation of colonic cancer cells through activating PPARδ. Here, LAMTOR5 is linked to colonic neoplasm.