Intriguingly, we observed that the mRNA and protein levels of PPARδ were significantly elevated by transiently transfecting HBXIP expression plasmids (pCMV-HBXIP) in colonic cancer SW480 and HT-29 cells (Figure 1A, 1B and Supplementary Figure 1B). Here, PPARD is linked to malignant colon neoplasm.