PYCARD and mesothelioma: In addition to endogenous levels of inflammasome related genes in mesothelioma cells, the doxorubicin-induced inflammasome activation (caspase-1 and ASC) and related cytokines and growth factors (IL-1β, FGF2, G-CSF, TFPI2 and HMGB1) secreted levels in medium were also blocked by XMD8-92 pre-treatment in H2373 cells (Figure 5A).