HMGB1 and mesothelioma: Treatment of H2373 or Hmeso mesothelioma cells with XMD8-92 for varied time points (24–72 h) inhibited steady-state mRNA levels of constitutive inflammasome partners and related genes like caspase-1, IL-1α, IL-1β, HMGB1 and PYCARD (encodes ASC protein) as compared to respective controls in both cell types (Figure 4A, 4B).