In the therapeutic model (Figure 4C and 4D), by day 21 after NS-1 mouse myeloma cells were inoculated into mice, the mean volumes of in NS group, the Vector group, the HSP70 group, the mDKK1 group, the hDKK1 group, the mDKK1- hHSP70 group, the hDKK1-hHSP70 group were 1926 ± 215 mm3, 1855 ± 157 mm3, 1506 ± 71.5 mm3, 1193 ± 152 mm3, 1008 ± 84.5 mm3, 796 ± 73.4 mm3 and 498 ± 95.2 mm3, respectively. The gene discussed is DKK1; the disease is plasma cell myeloma.